2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (2024)

College basketball fans everywhere are ecstatic because, after a long wait, the 2021 NCAA Tournament is here. After COVID-19 canceled March Madness in 2020, the greatest event in sports is back! All day Friday, we'll be treated with overlapping hoops action as the bracket slowly begins to take shape.

The first-round has already delivered some fantastic moments. None have been bigger than that of No. 15 seed Oral Roberts scoring the shocking upset of No. 2 seed Ohio State on Friday. The Eagles secured their first tournament win since 1974 and became just the ninth No. 15 seed to ever win against a No. 2 seed.

To gear up for the rest of the day, our team has compiled their picks for every game Friday so scroll away and get a feel for who we like -- and don't like -- before you throw down some hard-earned cash on the action.

Who wins and covers every game? And which teams should be on upset alert?Visit SportsLine now to see which team to back in every matchup, all from the model that's up $2,600 for $100 players.

(11) Syracuse vs. (6) San Diego State

Time: 9:40 p.m. |Location: Hinkle Fieldhouse
TV:CBS|Live stream: March Madness Live

Syracuse and San Diego State have one thing in common: They both play close games a lot. So while I like San Diego State and the MWC-winning Aztecs a lot, I have a hard time thinking this one will be anything other than a one-possession game by the end. Prediction: San Diego State 69, Syracuse 68. -- Boone


2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (1)

Gary Parrish

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (2)

Matt Norlander

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (3)

Jerry Palm

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (4)

Chip Patterson

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (5)

Kyle Boone

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (6)

David Cobb

SDSU -3

Syracuse

San Diego St

Syracuse

Syracuse

Syracuse

San Diego St

S/U

Syracuse

San Diego St

Syracuse

Syracuse

San Diego St

San Diego St

(14) Morehead State vs. (3) West Virginia

Time: 9:50 p.m. |Location: Lucas Oil Stadium
TV: truTV |Live stream: March Madness Live

West Virginia's mountain-of-a-man Derek Culver may not be the mismatch that most teams would consider thanks to the late-season emergence of Morehead State freshman big man Johni Broome. But the Mountaineers have guards they can throw at you in waves between Deuce McBride, Sean McNeil and Taz Sherman, making this a game that WVU should handle with relative ease. Should.. Prediction: West Virginia 70, Morehead State 62. -- Boone


2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (19)

Gary Parrish

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (20)

Matt Norlander

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (21)

Jerry Palm

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (22)

Chip Patterson

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (23)

Kyle Boone

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (24)

David Cobb

WVU -12.5

W. Virginia

Morehead St.

W. Virginia

W. Virginia

Morehead St.

W. Virginia

S/U

W. Virginia

Morehead St.

W. Virginia

W. Virginia

W. Virginia

W. Virginia

(12) Winthrop vs. (5) Villanova

Time: 9:57 p.m. | Location: Indiana Farmers Coliseum
TV: TNT |Live stream: March Madness Live

It's hard to overstate just how tough the loss of Collin Gillespie is for Villanova. The senior guard keyed the entire operation, and the Wildcats are 0-2 without him. If there's a worry with picking Winthrop, it's that the Eagles simply haven't been tested against to-notch competition. But they were so dominant in the Big South Tournament, and Villanova has looked so lackluster without Gillespie, that picking Winthrop to win here shouldn't even be considered an upset pick. Prediction: Winthrop 74, Villanova 72. -- Cobb


2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (37)

Gary Parrish

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (38)

Matt Norlander

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (39)

Jerry Palm

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (40)

Chip Patterson

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (41)

Kyle Boone

2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (42)

David Cobb

NOVA -6.5

Villanova

Winthrop

Winthrop

Winthrop

Villanova

Winthrop

S/U

Villanova

Winthrop

Winthrop

Winthrop

Villanova

Winthrop


(13)Libertyvs. (4)Oklahoma State

Time:6:25 p.m. |Location: Farmers Coliseum
TV:TBS |Live stream:March Madness Live

Trendy Oklahoma State is a darkhorse in the vaunted Midwest Region because of its recent hot streak and Cade Cunningham, but do not sleep on this Liberty team. It won 23 games behind a top-10 3-point attack in the country and a grind-it-out style akin toVirginia. If any team can kick the Pokes off their rhythm, it's this old, undersized Flames bunch.Prediction: Oklahoma State 77, Liberty 74 -- Boone


OSU -7.5
S/U

(9)Wisconsinvs. (8)North Carolina

Time:7:10 p.m. |Location: Mackey Arena
TV:CBS |Live stream:March Madness Live

These teams are trending hard in opposite directions, and UNC's talent edge should shine through here as the young Tar Heels try and blossom on the big stage. The flashes of brilliance shown by UNC recently make it the pick here. Wisconsin has simply been too inconsistent, despite having a veteran roster, and it's hard to pinpoint any position where the Badgers have a clear advantage.Prediction: North Carolina 83, Wisconsin 77 -- Cobb


OSU -7.5
S/U

(15)Cleveland Statevs. (2) Houston

Time:7:15 p.m. |Location: Assembly Hall
TV:truTV |Live stream:March Madness Live

Houston wasn't tested often in a weak AAC. But the Cougars have been elite defensively all season and have enough athletes to overpower Cleveland State. It's fair to wonder how Houston will fair past this game, but there shouldn't be any reason to worry about the Cougars in this matchup.Prediction: Houston 73, Cleveland State 60 -- Cobb


OSU -7.5
S/U

(13)North Texasvs. (4)Purdue

Time:7:25 p.m. |Location: Lucas Oil Stadium
TV:TNT |Live stream:March Madness Live

Don't let Purdue's one-and-done Big Ten tourney showing distract you from the fact that this team won its final five regular-season games and turned a corner behind its young stars in Jaden Ivey and Zach Edey. The Boilermakers have a fabulous blend of young and old on their roster that, together, makes them plenty capable of being a threat in the first round and beyond. Lay the points.Prediction: Purdue 71, North Texas 60 -- Boone


OSU -7.5
S/U

(10)Rutgersvs. (7)Clemson

Time:9:29 p.m. |Location: Bankers Life Fieldhouse
TV:TBS |Live stream:March Madness Live

Clemson boasts impressive depth, but success in the NCAA Tournament is often about star power, and Rutgers is better in that department with Ron Harper Jr. andJacob Young. Plus, the Scarlet Knights are breaking a 30-year NCAA Tournament drought here. They are going to be motivated to make their run last longer than a game. After going through the grind of the Big Ten schedule, this team is tested and ready to handle Clemson and its starAamir Simms.Prediction: Rutgers 67, Clemson 62. -- Cobb


OSU -7.5
S/U
2021 NCAA Tournament bracket predictions: March Madness picks, odds, lines for Round 1 games Friday (2024)

FAQs

What are the odds of picking a perfect NCAA tournament bracket? ›

Why is it so hard to pick a perfect bracket? The chances of picking a perfect bracket is: 1 in 2 to the 67th power, or 1 in 147,573,952,589,676,412,928, or about 147 quintillion. This assumes that each participant has a 50/50 chance of winning.

How do I score my March Madness bracket? ›

Here is a scoring breakdown for each round of play:
  1. First Round: 1 point.
  2. Second Round: 2 points.
  3. Sweet 16: 4 points.
  4. Elite 8: 8 points.
  5. Final Four: 16 points.
  6. Championship: 32 points.

How many chances are there in March Madness? ›

Various approaches have been taken to estimate the chance of predicting a perfect bracket. There are 263 or 9,223,372,036,854,775,808 unique combinations of winners in a 64-team bracket, meaning that without considering seed number, the odds of picking a perfect bracket are about 9.22 quintillion to 1.

Who has best odds to win NCAA tournament? ›

2025 NCAA Tournament championship odds
UConn+1000
Duke+1200
Houston+1600
Kansas+2000
North Carolina+2000
191 more rows
Apr 9, 2024

How to pick the best March Madness bracket? ›

  1. Don't start filling out your bracket with Round 1; start with the Elite Eight or Final Four.
  2. Look for value in the Elite Eight.
  3. Be selective picking upsets.
  4. The size of your pool will tell you how much risk to take.
  5. Don't buy into the 12-seed mystique. ...
  6. Believe in at least one 'First Four' team.
Mar 18, 2024

Has there ever been a perfect women's bracket? ›

Final perfect women's bracket busts on 51st game

An impressive run at perfection into the Sweet 16 came to a close, as the last perfect bracket picked its first game wrong when No. 3 NC State beat No. 2 Stanford, 77-67, on Friday night.

Who is most likely to win men's March Madness? ›

March Madness Power Rankings: Final Four
  • T-3) North Carolina State Wolfpack (+1600) In the never-ending fight against fate, destiny always wins. ...
  • 2) Purdue Boilermakers (+205) Basketball may very well be the most superstar-driven sport in the world. ...
  • 1) UConn Huskies (-195)
Apr 2, 2024

Who would win Purdue vs UConn? ›

Purdue is averaging 79.8 points per game during the tournament, while UConn is averaging 82.2. The Huskies are 6.5-point favorites in the latest Purdue vs. UConn odds from SportsLine consensus, while the over/under for total points scored is 143.5.

How many number 1 seeds have lost in the first round? ›

Despite numerous instances of early-round tournament upsets, only two No. 1 seeds have lost in the first round to a No. 16 seed.

Who is predicted to win March Madness 2024 women's? ›

The title game is set for the women's NCAA March Madness tournament. The South Carolina Gameco*cks will put their undefeated record on the line against Caitlin Clark and the Iowa Hawkeyes — and per usual, South Carolina is favored.

What are the odds for UConn to win the championship? ›

UConn is the favorite to win the 2025 national championship at ESPN BET and Caesars Sportsbook, opening with +900 and 10-1 odds, respectively.

How often does the favorite win the NCAA Tournament? ›

Since seeding began in 1979, 26 No. 1 seeds have won 26 national championships, the most of any seed. The rest of the other seeds have combined for just 18 titles. That means 59.1% of national champions since 1979 were top seeds.

How much for a perfect March Madness bracket? ›

Try $1 billion. That was the lucrative figure that Dan Gilbert from Quicken Loans (now Rocket Companies) and their insurer Berkshire Hathaway Inc. with its super billionaire Chair, Buffett, dangled to sports fans that year in exchange for 63 correct picks—aka a perfect March Madness bracket.

What is 9.2 quintillion written out? ›

The odds of filling out a perfect bracket are one in 9.2 quintillion. Written out, that's 9,223,372,036,854,775,808. CHARLOTTE, N.C. — March Madness is officially here.

How many 16 seeds beat a 1 seed? ›

1 Boilermakers were among the favorites to win it all, but it was the Knights that pulled off a 63-58 stunner. UMBC and Fairleigh Dickinson are the only No. 16 seeds to ever beat a No. 1 seed since the field expanded to 64 teams in 1985.

How many first round upsets on average? ›

Here's how to pick March Madness men's upsets, according to the data
AvgMost
Total Upsets8.514 (2021 and 2022)
First Round4.658 (2016)
Second Round3.136 (1996, 1990, 2018)
Sweet 160.261 (10 occasions)
2 more rows
Mar 19, 2024

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